![]() Patients with mild renal impairment (eGFR ≥60 to In patients with moderate renal impairment (eGFR ≥30 to Paxlovid is now supplied in two different dose packs, one for standard dosing and one for moderate renal impairment dosing. Is dose adjustment of Paxlovid needed for patients with moderate renal impairment? University of Liverpool COVID-19 Drug Interactions.Other resources regarding management of drugs with potentially significant drug interactions with Paxlovid include: Recommendations are provided in the Health Care Provider Fact Sheet and the Eligibility Screening Checklist Tool along with an alphabetized list of other drugs with potentially significant drug interactions. However, several commonly used medications with potential interactions such as statins, oral contraceptives, and HIV medications can be easily managed under provider supervision. Potential drug-drug interactions are an important consideration. Ritonavir is a strong inhibitor of cytochrome P450 3A. ![]() Paxlovid contains nirmatrelvir and ritonavir. The checklist is intended to support clinical decision making, and I believe it will be a helpful addition to any prescriber’s “toolbox.” We also developed a Prescriber Patient Eligibility Screening Checklist. ![]() FDA recently updated the Fact Sheet for Health Care Providers for Paxlovid to provide more specific recommendations for some drugs. Are there tools to help health care providers manage potential drug-drug interactions? We recognize that risk factors have changed over time, and that it is appropriate to consider vaccination status in assessing a patient’s risk for progression to severe COVID-19.įor more information on medical conditions and factors associated with increased risk for progression to severe COVID-19, please visit the Centers for Disease Control and Prevention (CDC) website. Patients do not have to have more than one risk factor to be considered “high risk”. Patients in the authorized population with a risk factor for progression to severe COVID-19 are eligible for Paxlovid under the EUA even if they are fully vaccinated. How should health care providers assess a patient for “high risk for progression to severe COVID-19”? Serologic tests are not considered to be direct SARS-CoV-2 viral tests. Confirmation of a positive home rapid antigen diagnostic test with additional direct SARS-CoV-2 viral testing, such as a PCR, is not required. ![]() A positive result on a PCR test also meets the requirement under the EUA to have a positive test result. Patients in the authorized population who report a positive home test result from a rapid antigen diagnostic test to their provider are eligible for Paxlovid under the emergency use authorization (EUA). There are many rapid antigen tests authorized for home use.
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